from Noam Chomsky's On Nature and Language:
The Galilean model of intelligibility has a corollary: when mechanism fails, understanding fails. The apparent inadequacies of mechanical explanation for cohesion, attraction, and other phenomena led Galileo finally to reject "the vain presumption of understanding everything." Worse yet, "there is not a single effect in nature...such that the most ingenious theorist can arrive at a complete understanding of it."
I'm not yet convinced.
Not proof of conjecture, but here are a few of my personal idols.
And unrelated, but of note, from about a year ago: How To Make A Carrot Cake (video)